“Glutathione, considered to be the master antioxidant (AO), is the most-important redox regulator that controls inflammatory processes, and thus damage to the periodontium. Periodontitis patients have reduced total AO capacity in whole saliva, and lower concentrations of reduced glutathione (GSH) in serum and gingival crevicular fluid, and periodontal therapy restores the redox balance. Therapeutic considerations for the adjunctive use of glutathione in management of periodontitis, in limiting the tissue damage associated with oxidative stress, and enhancing wound healing cannot be underestimated, but need to be evaluated further through multi-centered randomized controlled trials.

Oxidative stress in the pathogenesis of periodontitis is the result of an alteration in redox balance of the cells and tissues of innate immunity system. Glutathione, considered to be the master AO, is the most important redox regulator that controls inflammatory processes, and thus damage to the periodontium. Glutathione acts directly as a generic ROS scavenger or as a cofactor of GSHPX and GST, either by the conjugation/excretion processes of the Phase II reactions or by catalyzing the reduction of lipid hydroperoxides and H2O2.”

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